Regulation and Action of SKP2 in Cell and Tumor Models: Mechanisms Underlying Aggressive Growth in Basal-Like Breast Cancer

Abstract

The objective of this research is to further our understanding of the molecular mechanisms underlying the aggressive growth of estrogen receptor (ER)-negative, basal-like breast tumors. My goal is to determine if SKP2 is a viable new therapeutic target to specifically treat patients who have tumors that are independent of ER signaling. The most significant result was determining that knockdown of SKP2 in TMX2-28 cells shifted the cell cycle resulting in a significant increase in the percentage of cells in the G1/G0 phase, as well as a significant decrease in the percentage of cells in the S-phase of the cell cycle.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 2011
Accession Number
ADA561142

Entities

People

  • Katerina Fagan-solis

Organizations

  • University of Massachusetts Amherst

Tags

DTIC Thesaurus Topics

  • Biological Sciences
  • Biology
  • Biomedical Research
  • Breast Cancer
  • Cell Line
  • Cell Physiological Processes
  • Chemistry
  • Culture Techniques
  • Diseases And Disorders
  • Estrogens
  • Gene Expression
  • Genetics
  • Medical Personnel
  • Neoplasms
  • Students
  • Therapy
  • Tumor Cell Line

Fields of Study

  • Biology
  • Medicine

Readers

  • Materials Science and Engineering.
  • Mathematics or Statistics
  • Molecular Biology and Genetics