Biomarker Discovery and Mechanistic Studies of Prostate Cancer Using Targeted Proteomic Approaches

Abstract

Our findings reveal that EMMPRIN immunoreactivity was primarily detected among the glandular epithelial cells; EMMPRIN levels progressively increased with increasing age of TRAMP mice (6-27wks); with the highest detected in liver metastases. Quantitative analysis revealed that by 27-wks (an age exhibiting highly aggressive prostate tumor phenotype), EMMPRIN expression increased significantly (P=0.001). These results suggest that EMMPRIN may have diagnostic value in prostate cancer detection in advanced disease.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2011
Accession Number
ADA561372

Entities

People

  • Haining Zhu
  • Natasha Kyprianou

Organizations

  • University of Kentucky

Tags

DTIC Thesaurus Topics

  • Biology
  • Biomedical Research
  • Cancer
  • Carcinoma
  • Cells
  • Cytoskeleton
  • Department Of Defense
  • Detection
  • Diseases And Disorders
  • Epithelial Cells
  • Intercellular Junctions
  • Membrane Proteins
  • Metastasis
  • Neoplasms
  • Prostate
  • Prostate Cancer
  • Tissues

Readers

  • Neuroscience
  • Nuclear Civil Defense.
  • Oncology (Cancer Research).

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech