Adenovirus 36 Seropositivity is Strongly Associated With Race and Gender, But Not Obesity, Among U.S. Military Personnel
Abstract
Background. Several studies have shown a positive association between evidence of anti-Adenovirus 36 (Ad-36) antibodies (Ad-36 exposure) and (1) obesity and (2) serum cholesterol in animals. There is limited research on (1) demonstrating this association in humans and (2) transmission, presentation, and demographics of Ad-36 infection. Design: (1) Body mass, (2) fasting serum cholesterol/triglyceride levels, (3) and demographic characteristics were compared between Ad-36 seropositive and seronegative groups. Subjects: One hundred fifty obese and 150 lean active-duty military personnel were studied. Measurements: Subjects completed a questionnaire regarding demographic/behavioral characteristics. Subject serum samples were tested by neutralization assay for presence of Ad-36 antibodies. Results: Thirty-four percent of obese and 39% of lean subjects had Ad-36 exposure, an insignificant difference. Cholesterol/triglyceride levels were significantly higher among obese subjects than among lean, but there were no associations between cholesterol/triglyceride levels and Ad-36 exposure. Positive associations were found between Ad-36 exposure and age, race, and gender. Conclusion: The study stands in contrast to previous work that has shown a positive relationship between Ad-36 exposure and (1) obesity and (2) levels of /cholesterol and triglycerides. There was no association in either case. Unanticipated relationships between Ad-36 exposure and age, race, and gender were found.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 2010
- Accession Number
- ADA561593
Entities
People
- C. J. Hansen
- Christine M. Baker
- D. Metzgar
- K. Campbell
- K. L. Russell
- M. Irvine
- M. P. Broderick
Organizations
- Naval Health Research Center