Pathogenesis of Acute and Delayed Corneal Lesions After Ocular Exposure to Sulfur Mustard Vapor

Abstract

Sulfur mustard (SM) exposure results in dose-dependent morbidities caused by cytotoxicity and vesication. Although lesions resulting from ocular exposure often resolve clinically, an idiopathic delayed mustard gas keratopathy (MGK) can develop after a moderate or severe exposure. Sequelae include persistent keratitis, recurring epithelial lesions, corneal neovascularization, and corneal degeneration, which can lead to impaired vision or loss of sight. The purpose of this effort is to correlate structural changes with injury progression during the development of MGK.

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Document Details

Document Type
Technical Report
Publication Date
Mar 01, 2012
Accession Number
ADA561859

Entities

People

  • Adam Swartz
  • Angela Adkins
  • Denise Milhorn
  • Marian Nelson
  • Patrick M. McNutt
  • Richard Lawrence
  • Tracey Hamilton

Organizations

  • United States Army Medical Research Institute of Chemical Defense

Tags

DTIC Thesaurus Topics

  • Anti-Inflammatory Agents
  • Biomedical Research
  • Cell Physiological Processes
  • Cells
  • Chemical Warfare
  • Chemical Warfare Agents
  • Chemical Weapons
  • Cornea
  • Corneal Diseases
  • Endothelial Cells
  • Epithelial Cells
  • Epithelium
  • Microscopes
  • Microscopy
  • Pathogenesis
  • Rodents
  • United States

Fields of Study

  • Medicine

Readers

  • Geochemistry
  • Neurotrauma and Rehabilitation Medicine.