Plasma Endothelial Microparticles in Multiple Sclerosis: A Novel Metric Assay of Disease Activity and Response to Treatment

Abstract

The purpose of this research project is to validate plasma microparticle profiling in multiple sclerosis with the goal of defining microparticle species which have value as predictive or prognostic biomarkers. Additionally, the findings of this project Scope: These finding apply to both civilian and military patients with MS. Major Findings: We have now linked iron deposits in specific brain structures in MS with particular microparticle species; some of these data have been presented at the last international society for neurovascular disease. Up to date report: We are continuing with patient recruitment and processing of samples and are collecting timed patient samples after recruitment towards completion of the project.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2011
Accession Number
ADA561970

Entities

People

  • Alireza Minagar
  • Jonathan S. Alexander

Organizations

  • Louisiana State University

Tags

DTIC Thesaurus Topics

  • Biological Factors
  • Biomedical Research
  • Blood
  • Blood-Brain Barrier
  • Brain
  • Cells
  • Central Nervous System
  • Chemistry
  • Databases
  • Department Of Defense
  • Diseases And Disorders
  • Institutional Review Board
  • Medical Personnel
  • Microparticles
  • Multiple Sclerosis
  • Proteins
  • Side Effects

Fields of Study

  • Medicine

Readers

  • Aerosol Science/Aerosol Physics
  • Molecular and Cellular Biology
  • Oncology