The Role of SF2 in Prostate Cancer Progression

Abstract

Prostate cancer (a leading cause of male mortality) development and progression is dependent upon androgen and androgen receptor (AR) signaling. Current therapies target androgen production and/or AR signaling. Evidence suggests that AR in some tumors may escape therapy through mechanisms that likely involve splicing. Purpose: To better understand splicing during prostate cancer development or progression. Scope: As outlined in the proposal (and published) observations suggest that the splicing factor (SF2) may contribute to prostate cancer in part through altered D-cyclin splicing. Findings to date: have been made on determining the status, using a recently developed immunohistochemical approach, of SF2 in human prostate cancer specimens. Progress has also been made on determining the biological relevance in prostate cancer-derived cell model systems with altered levels of SF2 that mimic human disease. Simultaneous efforts have been made to develop targeted knockdown of SF2 to decipher the SF2-mediated splicing repertoire in prostate cancer.

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Document Details

Document Type
Technical Report
Publication Date
Apr 01, 2012
Accession Number
ADA562121

Entities

People

  • Betty Diamond
  • Clay Comstock

Organizations

  • Thomas Jefferson University

Tags

DTIC Thesaurus Topics

  • Androgen Receptors
  • Androgens
  • Biological Staining And Labeling
  • Biomedical Research
  • Cancer
  • Cell Line
  • Cells
  • Demographic Cohorts
  • Deprivation
  • Diseases And Disorders
  • Epithelial Cells
  • Gene Expression
  • Neoplasms
  • Prostate
  • Prostate Cancer
  • Proteins
  • Tissues

Fields of Study

  • Biology

Readers

  • Military Engineering.
  • Oncology (Cancer Research).
  • Prostate Cancer Biology.