ProCEED Pilot Study (Prostate Cancer Study of Ethnicity, Exercise and Diet)
Abstract
Prostate cancer has a huge and growing burden of disease, yet its natural history has not been fully elucidated. Several studies have shown a positive association between IGF-1 and prostate cancer, suggesting that perhaps increased levels of this hormone could be considered a risk factor for the disease. The ProCEED study was undertaken to examine whether levels of serum IGF-1 were higher in prostate cancer patients vs patients without prostate cancer. Prostate cancer cases and non-cancer controls were recruited in a Veteran s Administration general urology clinic setting. Clinical / sociodemographic data and blood draws for ascertainment of laboratory assays were collected during the study visit and by reviewing medical records. Only African-American and Caucasian men over the age of 50 who lived in the state of Illinois were included in the study. Patients were classified as prostate cancer cases if they had recent biopsyproven adenocarcinoma. Controls were required to have a negative digital rectal exam at the study visit, no history of BPH or prostate cancer, and two normal PSA values (one within one year of study entry). Univariate group means were compared using t-tests or Cochran Mantel-Haenszel tests as appropriate. Multivariable analysis was performed using logistic regression methods, with prostate cancer status as the dependent variable.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 01, 2010
- Accession Number
- ADA562840
Entities
People
- Katrine L. Wallace
Organizations
- University of Illinois at Chicago