Wound Trauma Alters Ionizing Radiation Dose Assessment

Abstract

Wounding following whole-body-irradiation (radiation combined injury, RCI) increases mortality. Wounding-induced increases in radiation mortality are triggered by sustained activation of inducible nitric oxide synthase pathways, persistent alteration of cytokine homeostasis, and increased susceptibility to bacterial infection. Among these factors cytokines along with other biomarkers have been adopted for biodosimetric evaluation and assessment of radiation dose and injury. Therefore, wounding could complicate biodosimetric assessments.

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Document Details

Document Type
Technical Report
Publication Date
Jun 11, 2012
Accession Number
ADA563365

Entities

People

  • Bradley R. Garrison
  • G. David Ledney
  • Ian C. Dews
  • Juliann G Kiang
  • Lynnette H. Cary
  • Min Zhai
  • Patrick H. Ney
  • Risaku Fukumoto
  • Thomas B. Elliott
  • True M. Burns

Organizations

  • Armed Forces Radiobiology Research Institute

Tags

DTIC Thesaurus Topics

  • Blood
  • Blood Cells
  • Body Weight
  • Bone Marrow Cells
  • Cardiovascular System
  • Cells
  • Granulocytes
  • Ionizing Radiation
  • Leukocytes
  • Lymphocytes
  • Medical Personnel
  • Radiation
  • Radiation Injuries
  • Rodents
  • Stem Cells

Fields of Study

  • Medicine
  • Physics

Readers

  • Cardiovascular Physiology
  • Nuclear and Radiation Engineering.
  • Trauma or Military Medicine