Mathematical Modeling of Circadian and Homeostatic Interaction
Abstract
The PIs constructed a novel network modeling framework that is uniquely suited to investigating the neuronal regulation of sleep and wake states. Using this novel framework, the PIs have modeled interactions among primary brainstem and hypothalamic nuclei involved in sleep-wake regulation. The model network exhibits realistic sleep-wake behavior consisting of wake, rapid eye movement (REM) sleep, and non-REM (NREM) sleep states. Using this mathematical modeling framework, the PIs conducted modeling studies on several fronts investigating circadian and homeostatic regulation of sleep-wake behavior. Results have contributed to scientific progress in the experimental manipulation of neurotransmitter environments in specific neuronal populations through targeted microinjection of neurotransmitter agonists and antagonists; the feed-forward and feedback synaptic interactions between the SCN and sleep-wake nuclei that provide circadian modulation of sleep-wake behavior; the hypothesis that sleep-wake regulatory mechanisms are preserved across mammalian species; and the competing proposed network structures for the regulation of REM sleep.
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 16, 2011
- Accession Number
- ADA563698
Entities
People
- Cecilia Diniz Behn
- Daniel Forger
- Victoria Booth
Organizations
- University of Michigan