Loss of PTEN as a Predictive Biomarker of Response to Lithium Chloride, A Potential Targeted Treatment for Breast Cancer

Abstract

During the second year of this project, Tasks 1c and 2a have been completed. This includes biochemical and phenotypical characterization of isogenic breast cell lines with heterozygous and homozygous PTEN loss and a library of other cell lines which each represent a distinct mutation of the PI3K/mTOR pathway. Exposure of various isogenic pairs of PTEN knock out cell lines to lithium chloride has also been completed.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 2012
Accession Number
ADA564012

Entities

People

  • Michaela Higgins

Organizations

  • Massachusetts General Hospital

Tags

DTIC Thesaurus Topics

  • Antibodies
  • Biomedical Research
  • Breast Cancer
  • Cancer
  • Cell Line
  • Cells
  • Department Of Defense
  • Epithelial Cells
  • Growth Factors
  • Health Services
  • Knocking
  • Neoplasms
  • Oncology
  • Proteins
  • Spreadsheet Software
  • Standards
  • Statistical Analysis

Fields of Study

  • Biology

Readers

  • Electrochemical Engineering/ Fuel Cell Technologies
  • Molecular and genetic basis of cancer.
  • Oncology (Cancer Research).