Fibroblast Growth Factor 2: An Epithelial Ductal Cell Growth Inhibitor That Drops Out in Breast Cancer
Abstract
Our main objective is to establish whether the growth factor called FGF that is found in the breast merits the development as a target in a new breast cancer therapeutic drug discovery program. We are investigating whether a dysinhibition model of breast cancer progression is correct by asking the question does changing FGF content in mammary cancer change cancer progression. If so, we would justify setting up drug screening initiative to discover agonists, if not antagonists would be the preferred target. To meet this objective we are exploiting a mouse model of spontaneous mammary tumor development and creating lines of mice that are cancer prone/resistant by engineering a lack one of the presumed regulators of tumor growth, FGF2.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2009
- Accession Number
- ADA564059
Entities
People
- Andrew Baird
Organizations
- University of California, San Diego