Development of a Novel Microfluidic Platform for Multiple Sclerosis Study

Abstract

Neural stem cells (NSC) are multipotent cells isolated from striatal tissue and the subventricular zone, which is one of a few neurogenic areas in the adult brain. Evidence suggests that NSC proliferation and differentiation occur under physiological conditions and can be enhanced in certain pathological conditions following neural damage. However, the communication between soluble factors of inflammatory T cells and NSCs that affect the proliferation and differentiation of NSCs remain unknown. The goal of this project is to develop a novel NSC culture platform that is capable of both compartmentalizing and fluidically isolating microdomains of NSCs.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2012
Accession Number
ADA564418

Entities

People

  • In H. Yang

Organizations

  • Johns Hopkins University

Tags

DTIC Thesaurus Topics

  • Autoimmune Diseases
  • Biomedical Research
  • Blood
  • Brain
  • Cells
  • Central Nervous System
  • Diseases And Disorders
  • Fluorescent Dyes
  • Lymphocytes
  • Multiple Sclerosis
  • Nervous System
  • Platforms
  • Sclerosis
  • Stem Cells
  • Visual Inspection

Readers

  • Molecular and Cellular Biochemistry
  • Neuroscience

Technology Areas

  • Biotechnology