Diet Restriction and Fasting Exacerbate the Toxicity of Soman in Young and Old Guinea Pigs
Abstract
This study evaluated the effects of age (60 vs. 150 days), diet restriction (ad libitum vs. 80%), and fasting (recently fed vs. fasted 18 h) on survival, toxic signs, body weight, blood glucose, carboxylesterase, acetylcholinesterase, and butyrylcholinesterase in male guinea pigs exposed acutely to 0, 0.6, or 1.0 LD50 soman subcutaneously. Following soman exposure, body weight decreased but recovered by 1 week. Acetylcholinesterase levels were significantly decreased at all post-exposure time points (up to 1 week). Butyrylcholinesterase levels were suppressed out to 48 h post-exposure, but recovered by 1 week. Toxic signs were more severe in diet-restricted animals than ad libitum animals. Young animals exhibited more severe signs of toxicity than old animals. All animals in the saline and 0.6 LD50 groups survived to 1 week. For the 1.0 LD50 groups, old animals exhibited significantly greater survival (44.4%) than young animals (16.7%). Ad-libitum animals had significantly longer mean survival (87.7 h) times than diet-restricted animals (55.5 h), demonstrating a toxicity-enhancing effect of diet restriction.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2012
- Accession Number
- ADA564521
Entities
People
- Jeffrey L. Langston
- Todd M. Myers
Organizations
- United States Army Medical Research Institute of Chemical Defense