In Search of an Effective in vivo Reactivator for Organophosphorus Nerve Agent-Inhibited Acetylcholinesterase in the Central Nervous System

Abstract

Organophosphorus nerve agents irreversibly inhibit the enzyme acetylcholinesterase (AChE), leading to excessive cholinergic neurotransmission and causing toxic lethal consequences. Current nerve agent therapies in the U.S. include 2-pralidoxime to reactivate inhibited AChE. Due to its quaternary structure, this oxime does not readily cross the blood brain barrier (BBB) to reactivate brain AChE and to mitigate CNS toxicity.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 2012
Accession Number
ADA566089

Entities

People

  • Irwin Koplovitz
  • John H. McDonough
  • Robert K. Kan
  • Tsung-Ming Shih

Organizations

  • United States Army Medical Research Institute of Chemical Defense

Tags

DTIC Thesaurus Topics

  • Acetylcholinesterases
  • Animals
  • Biomedical Research
  • Blood
  • Blood Cells
  • Blood-Brain Barrier
  • Brain
  • Cardiovascular System
  • Cells
  • Central Nervous System
  • Laboratory Animals
  • Nerve Agents
  • Nervous System
  • Rodents
  • Skeletal Muscle
  • Spinal Cord
  • United States

Readers

  • Neurotoxicology