Architecture and Performance Analysis of General Bio-Molecular Networks

Abstract

This project provided a detailed framework to describe the components, reactions, and internal and external connections of the cellular control systems, developed a stochastic model of the generalized biomolecular network and obtained an analytic approach for the solution of the stochastic molecular network. Specifically, we have (1) Derived a novel and explicit iterative method (both the forward iterative method and backward iterative method) to calculate the solution of the Network Chemical Master Equation (CME); (2) Completed the numerical analysis based on our novel method and simulation analysis based on the nature of the molecular network for an example; (3) The result from numerical analysis and simulation analysis is almost exact same, which confirmed the correction of our theoretical result; and (4) The time to calculate the solution of CME by using our method is about 10 times faster than the time to calculate it by using the standard method. Our method is expected to be much better, in terms of the running time, for the system with more molecules.

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Document Details

Document Type
Technical Report
Publication Date
Jan 14, 2012
Accession Number
ADA566336

Entities

People

  • Wei W. Li

Organizations

  • Texas Southern University

Tags

Communities of Interest

  • C4I

DTIC Thesaurus Topics

  • Air Force
  • Air Force Research Laboratories
  • Chemical Reactions
  • Computational Science
  • Computer Science
  • Control Systems
  • Electronic Mail
  • Equations
  • Molecules
  • Numerical Analysis
  • Probability
  • Probability Density Functions
  • Probability Distributions
  • Random Variables
  • Reaction Time
  • Simulations
  • Standards

Readers

  • Computational Modeling and Simulation
  • Neural Network Machine Learning.
  • Operations Research