Minocycline and N-acetylcysteine: A Synergistic Drug Combination to Treat Traumatic Brain Injury
Abstract
Due to the changing nature of war, there is a pressing need for new treatments for traumatic brain injury (TBI). The grantee previously found screened that the combination of minocycline (MINO) and N-acetyl cysteine (NAC) synergistically improved brain function when dosed one hour following closed cortical impact (CCI) in rats. The overall objective of this proposal is that MINO/NAC synergistically improves brain function following TBI. Four tasks will be done to achieve this objective: 1) Differing doses of MINO/NAC will be tested for the ability to improve behavior and histology following moderate CCI. 2) MINO/NAC was effective when dosed one hour after injury. Longer intervals between injury and drug dosing will be tested. 3) TBI is clinically heterogenous; MINO/NAC should restore brain function following an additional TBI model, lateral fluid percussion. 4) A restoration of cognitive function will be tested three months after CCI. The grantee has received both institutional and DoD approval for the animal experiments in this work and has trained a MD-Ph.D. candidate to perform these studies.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2011
- Accession Number
- ADA566658
Entities
People
- Peter Bergold
Organizations
- State University of New York