Neuroprotective Strategies after Repetitive Mild Traumatic Brain Injury

Abstract

To explore two new neuroprotective strategies in the setting of experimental repetitive mild traumatic brain injury (mTBI): i) hyperbaric oxygen (HBO) preconditioning and ii) HBO treatment combined with intranasal delivery of nicotinamide (NAD). Scope: In rat model of a repetitive mild cortical controlled injury, we investigated the neuropathological profile of two mTBI sessions at two interval times (3, 7d) using non-invasive MRI assessments (T2WI, SWI, and DTI), correlated with histology. The effects of i) a prophylactic HBO strategy (pretreatment 3d X 1hr) prior to first mTBI and ii) the comprehensive therapeutic strategy of 3d X 1hr course of HBO combined with intranasal administration of NAD right after the first mTBI impact will be evaluated using the MRI and histological biomarkers.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 2011
Accession Number
ADA566666

Entities

People

  • Andre Obenaus

Organizations

  • Loma Linda University

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Brain
  • Brain Injuries
  • Cardiovascular Physiological Phenomena
  • Cerebral Edema
  • Cerebrovascular Disorders
  • Health Services
  • Medical Personnel
  • Neurodegeneration

Fields of Study

  • Medicine

Readers

  • Fluid Dynamics.
  • Neurotrauma and Rehabilitation Medicine.