Nano-Engineered Drug Combinations for Breast Cancer Treatment

Abstract

We hypothesis that nanoparticles can increase the efficacy of combination therapies for cancer. The project aims to explore nanoparticle-based transport vehicles for effective delivery of two different cancer drugs. In particular, we aim to use two breast cancer drugs, which enhance each other s efficacy and use them as a model drug pair for the development of novel dual-drug nano-therapeutics. The research to date has been focused on extending existing electrohydrodynamic co-jetting technology in the Lahann lab towards the simultaneous release of two independent small molecule drug surrogates.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 2012
Accession Number
ADA566728

Entities

People

  • Joerg Lahann

Organizations

  • University of Michigan

Tags

DTIC Thesaurus Topics

  • Biomedical Engineering
  • Biomedical Research
  • Breast Cancer
  • Cells
  • Combination Therapy
  • Confocal Laser Scanning Microscopy
  • Drug Combinations
  • Electron Microscopy
  • Materials
  • Molecular Weight
  • Molecules
  • Nanoparticles
  • Neoplasms
  • Particles
  • Scanning Electron Microscopy
  • Self Assembly
  • Therapy

Fields of Study

  • Biology

Readers

  • Nanocomposite Materials Science
  • Oncology (Cancer Research).

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech