Redox Regulation in Bone Marrow Failure

Abstract

Bone marrow failure is a group of hematopoietic stem cell disorders that affect one or more lineages of blood cells. Although the causes for bone marrow failure are complicated and not completely understood, oxidative stress has been recognized as a key contributor [1] [2] [3] [4] [5] [6]. Hematopoietic stem cells are highly sensitive to reactive oxygen species (ROS) [7, 8]. Accumulation of ROS activates p38, shortens the life span of hematopoietic stem cells, disrupts the homeostasis of hematopoietic stem cells, and eventually causes bone marrow failure [7, 8] [9] [10]. The key role of p38 in the development of bone marrow failure has also been demonstrated by the finding that treating aplastic anemia patients with a p38 MAPK inhibitor can restore defective hematopoietic activity, suggesting the critical role of p38 in bone marrow failure [11].

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 2012
Accession Number
ADA566819

Entities

People

  • Shi Pan

Organizations

  • Thomas Jefferson University

Tags

DTIC Thesaurus Topics

  • Blood
  • Blood Cells
  • Bone Marrow
  • Bone Marrow Cells
  • Cell Count
  • Cell Physiological Processes
  • Cells
  • Growth Factors
  • Hematologic Diseases
  • Hematopoiesis
  • Hematopoietic System
  • Leukocytes
  • Oxidative Stress
  • Proteins
  • Stem Cells

Readers

  • Immunology and Pathology

Technology Areas

  • Biotechnology