Mechanisms of Mitochondrial Dysfunction in Autism

Abstract

The purpose of this study is to define correlations between indices of brain dysfunction, such as functional MRI (fMRI) and neuropsychological testing abnormalities, with oxidative phosphorylation (OXPHOS) defects in children with autistic spectrum disorders (ASD). This study is an essential step in identifying such a phenotypic subtype, being able to perform large-scale epidemiological studies using more widely available measures, and ultimately being able to implement clinical trials for new pharmaceutical agents emerging for treatment of the OXPHOS defects which could significantly improve the functioning of children with ASD with this defect. In the current year, we have continued enrolling subjects into the study and have also begun gathering data on these subjects. We have begun analyzing these data, however, data acquisition is ongoing and larger numbers of subjects are needed before we will be able to draw meaningful conclusions from this study.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2012
Accession Number
ADA567077

Entities

People

  • John Shoffner

Organizations

  • Georgia State University

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Abnormalities
  • Acquisition
  • Alzheimer Disease
  • Cell Line
  • Cells
  • Clinical Trials
  • Cytoplasmic Structures
  • Data Acquisition
  • Data Analysis
  • Department Of Defense
  • Diseases And Disorders
  • Dysfunction
  • High Resolution
  • Metabolic Diseases
  • Phosphorylation
  • Proteins
  • Statistical Analysis

Fields of Study

  • Medicine

Readers

  • Child and Adolescent Substance Abuse Science in Autism Spectrum Disorders.
  • Molecular and Cellular Biology
  • Systems Analysis and Design