Mechanisms of Mitochondrial Dysfunction in Autism

Abstract

The purpose of this study is to define correlations between indices of brain dysfunction, such as functional MRI (fMRI) and neuropsychological testing abnormalities, with oxidative phosphorylation (OXPHOS) defects in children with autistic spectrum disorders (ASD). This study is an essential step in identifying such a phenotypic subtype, being able to perform large-scale epidemiological studies using more widely available measures, and ultimately being able to implement clinical trials for new pharmaceutical agents emerging for treatment of the OXPHOS defects which could significantly improve the functioning of children with ASD with this defect. In the current year, we have begun analyzing all prior laboratory data and enrolling qualified subjects into the study. The patients are being stratified into appropriate groups for the fMRI analyses. Additionally, control ranges have been established for fibroblast high resolution respirometry.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2011
Accession Number
ADA567094

Entities

People

  • John Shoffner

Organizations

  • Georgia State University

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Abnormalities
  • Biomedical Research
  • Cell Line
  • Cells
  • Clinical Trials
  • Cytoplasmic Structures
  • Data Analysis
  • Diseases And Disorders
  • Dysfunction
  • Endoplasmic Reticulum
  • High Resolution
  • Intracellular Membranes
  • Metabolic Diseases
  • Mitochondria
  • Phosphorylation
  • Statistical Analysis
  • Tissues

Fields of Study

  • Medicine

Readers

  • Clinical Trial Research.
  • Medical Imaging.
  • Molecular and Cellular Biology