Combinatorial Therapy Approaches for NF2-Deficient Meningiomas

Abstract

The aim of our research is to find novel targeted therapy for NF2 patients to provide a new therapeutic option for meningiomas that includes the standard of care radiotherapy. During the first year if this project we have successfully selected four small molecule compounds that preferentially inhibit NF2 mutant meningioma cells in vitro. These are FDA approved drugs that are safe for human use. We validated these drugs by using human cell lines and tested their ability to synergize with radiation. We have optimized the use of a CT-guided conformal radiation that can be tested in a meningioma mouse model. The findings obtained during the first year of this research project will be valuable for second phase, in which we will be testing combinatorial approaches in a meningioma mouse model.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 2012
Accession Number
ADA567130

Entities

People

  • Gilson S. Baia

Organizations

  • Johns Hopkins University

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Cell Line
  • Cells
  • Cultured Cells
  • Diseases And Disorders
  • Implantation
  • Inhibition
  • Inhibitors
  • Molecules
  • Neoplasms
  • Nervous System
  • Nervous System Diseases
  • Radiation
  • Radiotherapy
  • Small Molecules
  • Standards
  • Therapy

Fields of Study

  • Medicine

Readers

  • Data Mining and Knowledge Discovery.
  • Molecular and Cellular Biology
  • Oncology (Cancer Research).