The Use of Drugs to Reduce Hearing Loss Following Acute Acoustic Trama
Abstract
Following a 108 dB SPL, 4 kHz noise exposure for 6 hours, animals were treated in a rescue paradim with N-Acetyl l-cysteine, Ebselen, D-Methionine, Acetyl L-Carnitine or the Src protein tyrosine kinase inhibitor, KX1-004 and compared to untreated control subjects. Hearing loss, distortion product emissions and cochlear histology data were obtained in each animal. Statistical analyses indicated that there were no significant differences between the control and treated groups. The above five drugs were also applied in a rescue paradigm to groups of animals exposed to 10, 158 dB peak SPL blast waves. Data collection from two drug (L-NAC and D-MET) treated groups and one control group (N=20/group) is complete. Three groups (N=20/group) have been exposed and treated with ALCAR, Ebselen or Src Inh. Data collection and analysis on these groups is not complete. Variability in the response of animals to the blast exposures is a complicating factor. As a result of the variability in the blast wave control group, data on a second group (N=20) of noise only control subjects is being collected.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2012
- Accession Number
- ADA567238
Entities
People
- Roger Hamernik
Organizations
- State University of New York at Plattsburgh