Mitochondrial Based Treatments that Prevent Posttraumatic Osteoarthritis in a Translational Large Animal Intraarticular Fracture Survival Model
Abstract
Posttraumatic osteoarthritis is a debilitating consequence of intraarticular fractures. Patient outcomes after intraarticular fractures have not improved significantly in spite of improved surgical techniques. Therefore addressing the acute mechanical damage sustained by cartilage, a new treatment paradigm, offers a new approach to improve patient outcomes after such injuries. Military personnel are particularly disabled by intraarticular fractures. In this research, novel interventions directed at injury-related mitochondrial dysfunction and chondrocyte energy dysfunction are being tested in a small animal and a large animal translational model. These interventions have been successful in tissue level experiments. The interventions scavenge injury related excessive mitochondrial oxidants or prevent their formation, in addition to stimulating glycolytic ATP production. The treatments are designed to prevent chondrocyte death and improve chondrocyte function after an injury. The interventions will be used in an established rabbit model and subsequently in a porcine model of posttraumatic osteoarthritis.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2012
- Accession Number
- ADA567276
Entities
People
- Todd O McKinley
Organizations
- University of Iowa