Mission Connect Mild TBI Translational Research Consortium

Abstract

The goals of this section are to characterize the physiological, histological, cerebral vascular and behavioral effects of blastinduced neurotrauma (BINT) and to determine the effects of hemorrhagic hypotension (HH) after mTBI on physiological and pathophysiological outcome. These studies indicated that BINT resulted in reduced CBF and increased CVR, observations consistent with the presence of cerebral vasospasm. Our results that BINT impaired vasodilatory responses to reduced intravascular pressure in middle cerebral arterial segments, suggest that blast injury may increase vulnerability of the brain to the effects of hemorrhagic hypotension. These results are consistent with our observations that rats subjected to mild fluid percussion TBI prior to severe HH exhibit higher numbers of injured hippocampal neurons than rats subjected to HH without mTBI.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2012
Accession Number
ADA567351

Entities

People

  • Claudia Robertson
  • Douglas Dewitt

Organizations

  • Baylor College of Medicine

Tags

DTIC Thesaurus Topics

  • Acquisition
  • Animal Structures
  • Arteries
  • Blast Injuries
  • Blast Waves
  • Blood
  • Brain Injuries
  • Cardiovascular Diseases
  • Cardiovascular Physiological Phenomena
  • Data Acquisition
  • Diseases And Disorders
  • Health Services
  • Hypotension
  • Measurement
  • Medical Personnel
  • Observation

Fields of Study

  • Medicine

Readers

  • Cardiovascular Physiology
  • Neurotrauma and Rehabilitation Medicine.
  • Traumatic Brain Injury (TBI) and Cognitive Aging in the Guam and Border Populations Affected by Alzheimer's Disease and Tau-Associated Dementias.