A Forward Genetic Screening for Prostate Cancer Progression Genes
Abstract
It has been recently established that up to a hundred genetic alterations occur during the development of prostate cancer. Some of these mutations likely cause cancer progression while others could be passengers with no causative effect in tumor development. We are implementing a forward genetics approach for prostate cancer research, by first inducing tumors by random genetic alterations and then mapping the recurring mutations in the prostate cancer. This approach efficiently identifies mutations that drive cancer development and progression. Currently, we are screening and further optimizing our mutagenesis approach for maximum efficiency. In addition, we are collecting tumors and mapping causative genes. Once identified these genes will be validated in human patient samples. Identifying which mutations are responsible for tumor progression and metastasis will likely identify new avenues for treating advanced stage cancer.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2012
- Accession Number
- ADA567776
Entities
People
- Betty Diamond
- Tian Xu
Organizations
- Yale University