Psychophysiology of Delayed Extinction and Reconsideration in Humans
Abstract
Recent animal research suggests that reactivation (retrieval) of a consolidated memory can return it to a labile state from which it must be restabilized in order to persist. This stabilization process has been termed reconsolidation, and various behavioral and pharmacologic interventions have been found to modify or block it. The aim of this project is to create an experimental assay in the form of an optimal Pavlovian differential fear conditioning paradigm, within which the relative strengths of various novel pharmacological and behavioral, reconsolidation-blocking interventions can be tested. Thus far, we have successfully implemented the procedure, and are meeting or nearly meeting our recruitment goals. We have validated the novel fear conditioning paradigm by demonstrating differential conditioning in participants. Data collected to date have been subjected to preliminary analysis .Although several interesting trends are present, it is too early to draw conclusions. Subjects are continuing to be studied.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 01, 2012
- Accession Number
- ADA567826
Entities
People
- Roger Pitman
Organizations
- Massachusetts General Hospital