Minimizing Skeletal Muscle Injury to Ischemia/Reperfusion with Adenosine A3 Receptor Agonists: Role of Matrix Metalloproteases

Abstract

Today's Warfighter is subject to traumatic injuries to skeletal muscle. Tourniquet use for hemorrhage control is common, as well as in surgical situations requiring the restriction of blood flow to an extremity. The reperfusion period following prolonged tourniquet use results in skeletal muscle damage, making ischemia/reperfusion (I/R) injury a concern for military personnel. In regards to acute injury, 63% of injuries sustained in combat are the result of explosive munitions that produce traumatic injury in skeletal muscle.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2009
Accession Number
ADA567883

Entities

People

  • Bruce T. Liang
  • Edward J. Zambraski
  • Maria L. Urso

Organizations

  • United States Army Research Institute of Environmental Medicine

Tags

Communities of Interest

  • Human Systems
  • Space

DTIC Thesaurus Topics

  • Adenosine
  • Animal Structures
  • Azo Compounds
  • Biological Staining And Labeling
  • Blood
  • Blood Flow
  • Cells
  • Health Services
  • Information Operations
  • Intervention
  • Ischemia
  • Medical Personnel
  • Military Operations
  • Molecules
  • Muscle Cells
  • Recovery
  • Tissues

Fields of Study

  • Medicine

Readers

  • Trauma Surgery or Emergency Medicine.