Mammary Stem/Progenitor Cells and Cancer Susceptibility
Abstract
We proposed to define the quantitative relationship between inherited risk of developing mammary cancer and the number of MaSC under basal and hormone stimulated states in two well characterized inbred rat strains: 1) ACI, which is highly susceptible to 17 -estradiol (E2)-induced/progesterone (P)-dependent mammary cancer; and 2) Brown Norway (BN), which is highly resistant. Major findings: ACI and BN rats likely exhibit significant differences in MaSC number and/or responsiveness to hormone. Technical issues and loss of commercial source of BN rats led to revision of Aims. The data generated indicate that the susceptible ACI and resistant BN rat strains exhibit fundamental differences in their cellular response programs to E2. Whereas the mammary epithelium of the ACI proliferates in response to E2, the mammary gland of BN rats shows a slight proliferative response coupled with differentiation to secretory epithelium. We believe this difference in the cellular response to E2 stems from differences in MaSC and/or MaPC numbers or responsiveness to hormones, and that this these differences in turn explain, at least in part, the differing susceptibilities of these rat strains to E2-induced mammary cancer.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 2012
- Accession Number
- ADA567916
Entities
People
- James D. Shull
Organizations
- University of Wisconsin–Madison