Echo-Planar Imaging Based J-Resolved Spectroscopic Imaging for Improved Metabolite Detection in Prostate Cancer
Abstract
To implement an echo-planar imaging (EPI)-based 2D J-resolved spectroscopy on a 3T MRI/MRS scanner;2) To evaluate the multi-voxel 2D J-resolved echo-planar spectroscopic imaging (EP-JRESI) in malignant PCa patients, benign prostatic hyperplasia (BPH) patients and healthy prostates. 3) To develop and further optimize the ProFit algorithm to postprocess the multi-dimensional MRS data from different prostate pathologies. Scope: A major outcome is expected to be on improved detection (specificity) in differentiating malignant from benign prostate cancer using a novel four-dimensional (4D) EP-JRESI. Improved spectroscopic imaging techniques will enable unambiguous detection of metabolites and the lipids in situ, which could potentially complement the existing diagnostic modalities commonly used in prostate cancer. Progress and Major Findings: The 4D EP-JRESI sequence was successfully implemented on a 3T MRI scanner using the Siemens IDEA pulse sequence compiler and multi-voxel 2D J-resolved spectra have been recorded using external as well as endorectal MRI coils. Endo-rectal 4D EP-JRESI data have been successfully recorded in 24 prostate cancer patients. Three peer-reviewed manuscripts have been published during the first year
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2012
- Accession Number
- ADA567967
Entities
People
- Michael A Thomas
Organizations
- University of California, Los Angeles