The Role of NF1 in Memory Retrieval
Abstract
This proposal studies the role of NF1 in mediating long-term memory retrieval in Drosophila. Over the last funding period, we devoted our efforts in two areas as (1) to determine the role of NF1 in retrieval of LTM and (2) to map neural circuits involved in aversive and appetitive memory retrieval. We made extensive efforts in figuring out problems we encountered in rescuing the NF1-dependent memory phenotype and now we are back to continue the proposed work. For mapping circuits involved in retrieval, we found that gamma and alpha/beta lobes, but not alpha'/beta' lobes, are involved in retrieval of either aversive or appetitive memory. This finding advances current understanding and also provides a basis for studying roles of NF1 in memory retrieval.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2012
- Accession Number
- ADA567970
Entities
People
- Yi Zhong
Organizations
- Cold Spring Harbor Laboratory