Novel Interventions for Heat/Exercise Induced Sudden Death and Fatigue

Abstract

Exertional and/or environmental heat stroke (ES) and exertional rhabdomyolysis (ER) has been reported in patients with diagnosis of Malignant Hyperthermia (MH). MH is a life-threatening pharmacogenetic disorder caused by mutations in the ryanodine receptor type 1 gene (RYR1) encoding skeletal muscle calcium release channel. Our goal is to identify RYR1 mutations associated with enhanced susceptibility to EHS/ER/MH by enrolling subjects diagnosed with these conditions and performing genetic screening. We also proposed to evaluate the ability of AICAR to prevent the MH response in MHS mice and pigs.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2012
Accession Number
ADA568013

Entities

People

  • John Capacchione
  • Nyamkhishig Sambuughin
  • Rolf Bunger
  • Sheila M. Muldoon
  • Susan L. Hamilton
  • Tarina Wallacer

Organizations

  • Baylor College of Medicine

Tags

DTIC Thesaurus Topics

  • Amino Acids
  • Anesthesia
  • Anesthesia And Analgesia
  • Biomedical Research
  • Caffeine
  • Death
  • Diseases And Disorders
  • Families (Human)
  • Genes
  • Heat Stroke
  • Hyperthermia
  • Medical Personnel
  • Muscles
  • Muscular Diseases
  • Mutations
  • Postoperative Complications
  • Skeletal Muscle

Readers

  • Cardiovascular Physiology
  • Gulf War Illness and Chronic Multisymptom Illness in Veterans.
  • Molecular and genetic basis of cancer.

Technology Areas

  • Biotechnology