Abnormal Vestibulo-Ocular Reflexesin Autism: A Potential Endophenotype

Abstract

The overarching objective of this study is to characterize abnormalities of vestibulo-ocular reflexes (VOR) in Autism Spectrum Disorder (ASD). Specific aim 1: Characterize horizontal VOR post-rotary nystagmus without optokinetic feedback using a velocity step test. We hypothesize that in ASD vertical eye movement intrusions during horizontal nystagmus will occur more frequently than normal, will be time-locked to horizontal nystagmus, and will differ from voluntary saccades. Specific aim 2: Characterize horizontal VOR without optokinetic feedback using sinusoidal oscillation tests. We hypothesize that gain and phase lag of horizontal VOR will differ in children with ASD compared to controls. Specific aim 3: Characterize in ASD vertical VOR and torsional VOR, both without optokinetic feedback. The present report covers the second year following award initiation. Complete research data have been obtained from one child with ASD and 18 typically developing children.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 2012
Accession Number
ADA568061

Entities

People

  • Keith D. White

Organizations

  • University of Florida

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Autism
  • Biomedical Research
  • Department Of Defense
  • Diseases And Disorders
  • Electronic Mail
  • Eye Movements
  • Feedback
  • Information Operations
  • Instructions
  • Maryland
  • Nystagmus
  • Universities

Fields of Study

  • Medicine

Readers

  • Brain and Cognitive Science; Experimental Psychology; Cognitive Neuroscience
  • Child and Adolescent Substance Abuse Science in Autism Spectrum Disorders.
  • Molecular and genetic basis of cancer.