Brain Biology Machine Initiative: Developing Innovative Novel Methods to Improve Neuro-Rehabilitation for Amputees and Treatment for Patients at Remote Sites with Acute Brain Injury
Abstract
As described in the 2008-2009 proposal, UO researchers articulated two related aims: 1) neurorehabilitation and 2) neuroinformatics and telemedicine. The activities and goals described here are a continuum of those proposed and executed under award W81XWH-07-2-0092. In aim one, we applied existing fMRI methods to rehabilitation of injuries that directly (e.g., traumatic brain injury) or indirectly (e.g., spinal cord injury or limb amputation) affect the organization of brain functions. Our work during the funding period contributed information on how amputation affects brain functioning and structure, particularly 'higher-order" processes in the premotor and parietal regions. We developed statistical tools to assist with the characterization of brain reorganization following amputation. We achieved a greater understanding of how traumatic brain injury (TBI) affects brain networks related to executive function. Finally, we developed lines of transgenic mice that reversibly model the effects of damage to specific brain regions with anatomical control for surpassing surgical lesions, a key achievement that facilitated our in vitro work. In aim two, we used our research on brain plasticity as a vehicle to better represent the flow of information, from injury site to tertiary care centers. This work involved the development of a set of tools to process neuroinformatic data based on dense-array EEG and high-resolution neuroimaging, which was based on.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2010
- Accession Number
- ADA568063
Entities
People
- Richard W. Linton
- Scott Frey
Organizations
- University of Oregon