PPAR Delta as a Therapeutic Target in Triple-Negative Breast Cancers

Abstract

PPAR is a member of peroxisome proliferators activated receptors which play important role in regulating cellular metabolisms. Basal-like breast cancers accounting for ~15% of all breast cancer cases tend to be very aggressive and have poor prognosis. Basal-like breast cancers are considered to be derived from mammary stem cells. Abnormal activation of Wnt signaling is often found in human basal-like breast cancers. Here we report that PPAR expression is induced by Wnt signaling in mammary stem cells. Activation of PPAR by its ligands and fatty acids promotes the proliferation of mammary stem cells. The proliferation of mammary cancer stem cells is stimulated by PPAR agonists. Activation of PPAR promotes while its inhibition suppresses the tumorigenesis of MMTV-Wnt1 transgenic mice. We also found that PPAR antagonist inhibits the proliferation and anchorage-independent growth of a human basal-like breast cancer cell line.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2012
Accession Number
ADA568147

Entities

People

  • Chao Qi

Organizations

  • Northwestern University

Tags

DTIC Thesaurus Topics

  • Breast Cancer
  • Cell Line
  • Cells
  • Cultured Cells
  • Epithelial Cells
  • Fatty Acids
  • Inhibition
  • Neoplasms
  • Stem Cells

Fields of Study

  • Biology

Readers

  • Breast cancer cell signaling and growth regulation.
  • Prostate Cancer Biology.
  • Women's Health and Cancer Risk Research: African American Women and Pregnancy Outcomes.

Technology Areas

  • Biotechnology