High Depth, Whole-Genome Sequencing of Cholera Isolates from Haiti and the Dominican Republic

Abstract

Whole-genome sequencing is an important tool for understanding microbial evolution and identifying the emergence of functionally important variants over the course of epidemics. In October 2010, a severe cholera epidemic began in Haiti, with additional cases identified in the neighboring Dominican Republic. We used whole-genome approaches to sequence four Vibrio cholerae isolates from Haiti and the Dominican Republic and three additional V. cholerae isolates to a high depth of coverage (>2000x); four of the seven isolates were previously sequenced.

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Document Details

Document Type
Technical Report
Publication Date
Sep 11, 2012
Accession Number
ADA568159

Entities

People

  • Crystal Ellis
  • Edward T. Ryan
  • Firdausi Qadri
  • Jason B. Harris
  • Lisa Hensley
  • Manolis Kellis
  • Rachel Sealfon
  • Regina C. Larocque
  • Stephen Calderwood
  • Stephen Gire

Organizations

  • United States Army Medical Research Institute of Infectious Diseases

Tags

DTIC Thesaurus Topics

  • Computer Science
  • Diseases And Disorders
  • Dominican Republic
  • Genetic Code
  • Genetic Structures
  • Genetics
  • Health
  • Health Services
  • Infectious Diseases
  • Lipopolysaccharides
  • Medical Personnel
  • Microbial Genome
  • Personal Information Managers
  • Public Health
  • Republic
  • Sequences
  • Therapy

Fields of Study

  • Biology

Readers

  • International Relations, focusing on Korea-Africa and North Korea-South Korea relations, and Nigeria-Latin American Relations.
  • Microbial Pathology
  • Molecular and genetic basis of cancer.

Technology Areas

  • Biotechnology