Association of Cytokine Candidate Genes with Severity of Pain and Co-Occurring Symptoms in Breast Cancer Patients Receiving Chemotherapy
Abstract
The purpose of the proposed project is to identify common genetic variations (i.e., single nucleotide polymorphisms and haplotypes) in cytokine genes, as well as psychological characteristics that are significantly associated with the severity of pain and co-occurring symptoms (i.e., fatigue, sleep disturbance, and depressive symptoms) in a sample of women receiving chemotherapy for breast cancer. Using cluster analysis, our team has previously and consistently found two extreme patient subgroups: patients who report symptoms uniformly low (i.e., low scores on pain, fatigue, sleep disturbance, and depressive symptom inventories), and patients who report symptoms as more severe (i.e., high scores on all four symptom inventories). By the end of Year 1, 236 breast cancer patients were enrolled across the three research sites (UCSF, Alta Bates Summit Medical Center, and El Camino Hospital), and data collection forms were scanned and output to statistical analysis software. Moreover, the DNA samples of the participants were sent to the UCSF Genome Core for genotyping, and we expect that genotyping will be complete within the next two months.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2012
- Accession Number
- ADA568165
Entities
People
- Dale J. Langford
Organizations
- University of California, San Francisco