Similar Pathogen Targets in Arabidopsis thaliana and Homo sapiens Protein Networks

Abstract

We study the behavior of pathogens on host protein networks for humans and Arabidopsis - noting striking similarities. Specifically, we preform k-shell decomposition analysis on these networks - which groups the proteins into various "shells" based on network structure. We observe that shells with a higher average degree are more highly targeted (with a power-law relationship) and that highly targeted nodes lie in shells closer to the inner-core of the network. Additionally, we also note that the inner core of the network is significantly under-targeted. We show that these core proteins may have a role in intra-cellular communication and hypothesize that they are less attacked to ensure survival of the host. This may explain why certain high-degree proteins are not significantly attacked.

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Document Details

Document Type
Technical Report
Publication Date
Sep 21, 2012
Accession Number
ADA568374

Entities

People

  • J. K. Wickiser
  • Paulo Shakarian

Organizations

  • United States Military Academy

Tags

DTIC Thesaurus Topics

  • Bacteria
  • Biological Sciences
  • Coefficients
  • Computer Science
  • Decomposition
  • Electrical Engineering
  • Gene Expression
  • High Density
  • Law
  • Materials
  • Microorganisms
  • New York
  • Pathogenic Bacteria
  • Proteins
  • Regression Analysis
  • United States
  • United States Military Academy

Readers

  • Molecular Genetics
  • Neural Network Machine Learning.
  • Strategic Security Studies