Efficacy of Gamma-glutamylcysteine (GGC) in Ischemia-reperfusion Injury

Abstract

Hemorrhagic shock is a leading cause of death in military combat and civilian trauma (Bellamy, 1984; Lieu, et al., 2004). Better understanding of the associated cellular biochemical changes that occur in ischemia-reperfusion (IR) injury can lead to efficacious therapies (Thomas et al., 2008). Therefore, we have been studying the feasibility of using gamma-glutamylcysteine (GGC) a dipeptide precursor for glutathione as a potential compound in modulating the oxidative stress associated with IR injury.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2012
Accession Number
ADA568392

Entities

People

  • Stanley T. Omaye

Organizations

  • Nevada System of Higher Education

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Biomedical Research
  • Department Of Defense
  • Education
  • Electronic Mail
  • Information Operations
  • Ischemia
  • Maryland
  • Oxidative Stress
  • Vascular Diseases

Fields of Study

  • Biology
  • Medicine

Readers

  • Molecular and Cellular Biochemistry
  • Trauma Surgery or Emergency Medicine.