New Methods of Low-Field Magnetic Resonance Imaging for Application to Traumatic Brain Injury

Abstract

We have been developing robust low-magnetic-field implementations of MRI (LFI) focused on brain imaging. In particular we have expanded our development of the LFI test bed to include two complimentary approaches: electromagnet and permanent magnet based test bed scanner systems. We are also developing injury-sensitive MRI based on converting the electron spin of free radicals associated with injury into nuclear polarization using the Overhauser effect and subsequently imaging that modified nuclear polarization using low-field MRI (OMRI). Much of the hardware development of the human head LFI test bed systems and the OMRI system is now complete. Application of the suite of techniques and technologies from our work could advise future development of a deployable device with a high diagnostic impact and could be transformative, enabling improved diagnosis and monitoring of battlefield injuries prevalent in TBI.

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Document Details

Document Type
Technical Report
Publication Date
Feb 01, 2012
Accession Number
ADA568601

Entities

People

  • Matthew S. Rosen

Organizations

  • Harvard College

Tags

Communities of Interest

  • Advanced Electronics
  • Biomedical

DTIC Thesaurus Topics

  • Acquisition
  • Brain Injuries
  • Compressed Sensing
  • Control Systems
  • Detection
  • Detectors
  • Free Radicals
  • Frequency
  • Frequency Modulation
  • Geometry
  • Health Services
  • High Resolution
  • Magnetic Fields
  • Magnetic Resonance
  • Magnetic Resonance Imaging
  • Power Supplies
  • Test Beds

Fields of Study

  • Physics

Readers

  • Medical Imaging.
  • Neurotrauma and Rehabilitation Medicine.
  • Quantum spin resonance or Electron Paramagnetic Resonance spectroscopy.

Technology Areas

  • Microelectronics
  • Microelectronics - Microelectromechanical Systems