Ovarian Mouse Models with Targeted Fallopian Tubal Carcinogenesis

Abstract

To test the idea that ovarian cancer arises from oviductal epithelium, spreads to the ovary, and presents as ovarian cancer, we generated a mouse model in which we can target genetic deletions to the oviductal epithelium. We are currently performing selective genetic deletion of ovarian cancer genes, such as TP53, Rb, and BRCA1 in oviductal epithelium in this mouse model.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2012
Accession Number
ADA568807

Entities

People

  • Jeremy Chien

Organizations

  • Mayo Clinic

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Anatomy
  • Biological Sciences
  • Biological Staining And Labeling
  • Biomedical Research
  • Cancer
  • Data Analysis
  • Department Of Defense
  • Electronic Mail
  • Epithelium
  • Information Operations
  • Neoplasms
  • Ovarian Cancer
  • Tissues
  • Urogenital System

Fields of Study

  • Biology

Readers

  • Immunology and Pathology
  • Regression Analysis.
  • Women's Health and Cancer Risk Research: African American Women and Pregnancy Outcomes.

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech