Fasciotomy Reduces Compartment Pressures and Improves Recovery in a Porcine Model of Extremity Vascular Injury and Ischemia/Reperfusion

Abstract

The objective of this study is to establish a model of extremity compartment syndrome following vascular injury\hemorrhage and ischemia/reprovision. An additional objective is to determine the effect of fasciotomy on measures of neuromuscular recovery. Methods: Yorkshire swine\e (75+/-5kg) underwent 35% blood volume hemorrhage, followed by 1, 3 and 6 hours of ischemia (n-17; 1HR, 3HR, 6HR) via iliac artery occlusion followed by repair and reperfusion. A second cohort (n=18) underwent fasciotomy of the anterior compartment of the hind limb following vascular repair (lHRwF\ 3HRwF, 6HR-F). Compartment pressures and measures of electromyographic (EMG) recovery were performed throughout a 14 day survival period and tissue histology examined at the completion of the study.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2012
Accession Number
ADA568830

Entities

People

  • Gabriel E. Burkhardt
  • Jerry R. Spencer
  • Lorne H Blackbourne
  • Nickolay P. Markov
  • Shimul Patel
  • Thomas J. Percival
  • Todd E Rasmussen

Organizations

  • 59th Medical Wing

Tags

DTIC Thesaurus Topics

  • Air Force
  • Arteries
  • Blood
  • Cardiovascular Physiological Phenomena
  • Health Services
  • Hemorrhagic Shock
  • Medical Personnel
  • Peripheral Nervous System
  • Surgery
  • Vascular Diseases
  • Vascular System Injuries

Fields of Study

  • Medicine

Readers

  • Brain and Cognitive Science; Experimental Psychology; Cognitive Neuroscience
  • Cardiovascular Physiology