Targeted Nanoparticles for Kidney Cancer Therapy
Abstract
The overall goal of this proposal is to test targeted carbon nanotubes for their ability to thermally ablate kidney cancer. Carbon nanotubes (CNTs) have been shown to be efficient transducers of near-infrared radiation for laser-induced thermal therapy of kidney cancer in animal models. However, the current generation of carbon nanotubes lacks the ability to selectively target cancer cells following systemic administration. In this proposal, we will develop carbon nanotubes designed to bind to uPAR, a surface receptor overexpressed in kidney cancers and supporting endothelium that is involved in growth, migration, proliferation, metastasis and angiogenesis. To date, we have demonstrated the overexpression of uPAR in kidney cancer cells and endothelial cells. We have shown that these cells are sensitive to nanotube-mediated thermal ablation. We have begun the synthetic steps required to create a nanotube conjugate with the targeting ligand. This grant is a mentor/predoctoral award which also focuses on training of the predoctoral candidate. In addition to carrying out the bench research described above, the trainee has also attended several national meetings on nanotechnology sponsored by the NCI and AACR. In the upcoming year, our plans are to complete the synthesis of nanoconjugates, explore their properties in vitro, and begin an examination of their properties in vitro.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2011
- Accession Number
- ADA569284
Entities
People
- Suzy V. Torti
Organizations
- Wake Forest University