Regulation and Function of Cytokines that Predict Prostate Cancer Metastasis
Abstract
Patients at high-risk for metastatic progression of prostate cancer are unfortunately treated too late. We identified biomarkers that help distinguish aggressive disease from those that do not progress following prostatectomy. Specifically, CX3CL1 and IL15 were identified to be down regulated in subjects that developed recurrent prostate cancer. The studies presented suggest that both CX3CL1 and IL15 significantly reduce the motility of prostatic epithelia (LNCaP), but interestingly had little effect on non-tumorigenic prostatic cells (BPH1). Further, these two cytokines similarly reduced adhesion of LNCaP cells to collagen I. However, sensitivity to aniokis was dramatically induced in the same cells by CX3CL1 and IL15. This data support the clinical observation of recurrent free subjects having greater expression of CX3CL1 and IL15. Further, these factors may even serve as anti-metastatic mediators, despite their limited effects on tumor cell proliferation.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2012
- Accession Number
- ADA569356
Entities
People
- Neil A. Bhowmick
Organizations
- Cedars-Sinai Medical Center