Gp140/CDCPI in the Development pf Prostate Cancer Metastasis
Abstract
The purpose of the research is to analyze the expression and function of gp140/CDCP1, a regulator of SRC kinase activity in prostate cancer. The scope of the project in year 3 is to determine expression in tissues from patients. The main results are from immunohistochemical analyses of gp140 in normal prostate epithelium, primary prostate cancer and metastatic prostate cancer. Gp140 RNA expression and protein membrane expression, but not total protein expression, are significantly decreased in primary cancers compared to normal epithelium. In metastatic disease, total gp140 protein expression decreases and is significantly lower in bone compared to soft tissue metastases. Overall, gp140 expression decreases during metastatic progression, supporting the concept that the loss of gp140 facilitates tumor metastasis.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 2012
- Accession Number
- ADA569430
Entities
People
- Beatrice S Knudsen
Organizations
- Cedars-Sinai Medical Center