Evaluating the Potential of Adipose Tissue-Derived MSCs as Anticancer Gene Delivery Vehicles to Bone-Metastasized Prostate Cancer

Abstract

Several publications have shown clear evidence of tumor-site specific localization of Adipose stem cells (ASC). Therefore, tumor-homing potential of ASCs are promising tools for delivering anti-cancer genes to metastatic sites. However, studies have documented that only a small percentage of the systemically injected ASCs are actually recruited to the tumor site. Furthermore, when cotransplanted with tumor cells in vivo, studies also showed that certain ASCs may increase tumor growth. Thus, identification of the tumorpromoting phenotype in ASCs, and a selection strategy to enrich ASCs with non-tumor-promoting activity but enhanced tumor-homing potential, will be crucial.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2012
Accession Number
ADA569520

Entities

People

  • Debasis Mondal

Organizations

  • Tulane University of Louisiana

Tags

DTIC Thesaurus Topics

  • Adipose Tissue
  • Anti-Bacterial Agents
  • Biomedical Research
  • Blood
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Culture Media
  • Culture Techniques
  • Department Of Defense
  • Gene Delivery
  • Gene Therapy
  • Health Services
  • Peptide Growth Factors
  • Stem Cells
  • Stromal Cells

Fields of Study

  • Biology
  • Chemistry

Readers

  • Immunology and Pathology
  • Oncology (Cancer Research).

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech