Role of Diet Modulation and AMPK in Ovaria Cancer Progression and Outcome
Abstract
Ovarian cancer is the leading cause of death from gynecologic malignancies in the United States. Given the ambiguity concerning the etiology, difficulties in early detection, absence of any markers, low survival rates and the overall obscurity related with ovarian cancer, more research is needed to identify factors and approaches that could improve ovarian cancer disease initiation, progression and disease free survival. One of these factors which has been largely unexplored is the influence of diet and the metabolic state of the patients. Unfortunately, the role of dietary factors in ovarian cancer prognosis is largely unknown. Particularly, no attention has been given to the metabolic state of a cancer cell and how this state can be modulated by calorie restriction. In our present work we have shown that mice on a high energy diet gain a significant amount of weight which is also reflected in higher levels of glucose, insulin and insulin growth factor (IGF-1) compared to mice on regular or 30% calorie restricted diet. The IGF-Insulin pathway has been shown to play a major role in ovarian cancer progression and contributes to the metabolic syndrome. The calorie restricted group showed lower levels of leptin and IGF-1 while higher levels of adiponectin. Altogether, our data shows that the type of diet significantly alters levels of physiological growth factors that may influence the growth of the tumor.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2012
- Accession Number
- ADA569526
Entities
People
- Ramandeep Rattan
Organizations
- Henry Ford Health