Translational Pharmacologic Efficacy Studies of Glial Growth Factor 2 (GGF2) in Spinal Cord Injury Models and in the Veterinary Clinical Setting
Abstract
The purpose of the multi-institutional translational project is to identify the most appropriate dosing schedule and route of administration of glial growth factor 2 (GGF2) in the treatment of rodent spinal cord injury and then to translate this work to dogs with naturally occurring spinal cord injury. The tolerability and pharmacokinetics of GGF2 in dogs will be determined using the dosing regimen identified in the first phase of the work, and then the efficacy of GGF2 will be determined in dogs with intervertebral disc herniations causing acute onset of paralysis. According to the schedule of work, the initial 18 months of research are being performed at the other institutions involved in this multi-institutional project. Work is scheduled to start at North Carolina State University (NCSU) in 2013 and we have completed an IACUC proposal that is approved at the NCSU level and has been submitted to the DOD for review in readiness to start this work.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2012
- Accession Number
- ADA569530
Entities
People
- Natasha J Olby
Organizations
- North Carolina State University