SIRT3 Is a Mitochondrial Tumor Suppressor and Genetic Loss Results in a Murine Model for ER/PR-Positive Mammary Tumors Connecting Metabolism and Carcinogenesis
Abstract
The goals of this synergistic project are to establish the mitochondria localized sirtuin protein SIRT3 as a tumor suppresso breast cancer and to define its role as a molecular link between aging and breast cancer. Sirt3 knockout mice develop ER/P positive breast tumors later in life. These ER/PR-positive tumors are histologically similar to breast tumors common in old women. In humans, loss of SIRT3 is seen in a significant fraction of breast cancers and may serve as a molecular biomark Molecular targets of SIRT3 deacetylation have been identified, including MnSOD and OSCP. Antibodies that recognize specific acetylated lysine residues targeted by SIRT3 in these molecules have been identified and validated and are being developed as potential novel biomarkers in breast cancer. These studies have enhanced our understanding of the molecula links between aging and breast cancer and provide novel potential biomarkers of breast cancer in humans.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2011
- Accession Number
- ADA569609
Entities
People
- Sarki Abdulkadir
Organizations
- Vanderbilt University Medical Center