Vitamin D and Related Genes, Race, and Prostate Cancer Aggressiveness
Abstract
The overall goal of the study is to examine whether altered vitamin D status (as measured by serum metabolites and by functional polymorphisms with genes related to vitamin D transport, metabolism and activity) is associated with increased risk of aggressive prostate cancer, and may explain some of the racial disparity seen in aggressive prostate cancer. The project activities, as outlined in the Statement of Work Tasks and Milestones, are running on schedule. The study team has been organized and participates in monthly conference calls (or more frequent as needed) to discuss study progress and data collection and analyses, IRB approval was obtained from all local institutions and the DoD HSRRB. Biospecimens have been shipped to two of the institutions and measurements of circulating concentrations of vitamin D metabolites, calcium and phosphorus are complete. Data has been requested and obtained from the parent study, PCaP. Data merging, clearing and analyses are underway. With large representation of African Americans in this investigation, the proposed research has tremendous potential to provide insights into a chronically underserved population carrying an unequal burden of disease.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2012
- Accession Number
- ADA569674
Entities
People
- Susan E Steck